Instrumentation and Computer Control course is specially designed to make the scientists and engineers capable of interfacing an experimental setup, automate the setup by computer controls, the book is unique in its treatment of the subject in terms of coverage and approach. The book adopts a "learning through doing" approach. Each chapter deals with a major topic in computer control system design related to hardware, firmware and software. The chapters proceed as a series of practical experiments -- the reader sets up a simple hardware system, develops and downloads a simple program, and immediately observes and tests the outcome. The book then reflects on the experimental results, evaluating the strengths and weaknesses of the technology or technique introduced, explores how precise the link is between theory and practice, and considers scaling up the applications in the wider context. This is one of a few books that explains how to automate a lab, industry etc., using own proprietary or commercially made instruments using hardware, firmware and software. The book can be used by automation engineers in the industry, physicists working in an experimental setup, embedded system engineers and students who are interested in PC interfacing projects. Every chapter includes all the interfacing buses, hardware firmware and software design.